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Genomic imprinting. The role of DNA methylation in human diseases was first explored in the context of genomic imprinting. Genetic imprinting is an epigenetic phenomenon in which the …

Genomic imprinting is a process of silencing genes through DNA methylation. The repressed allele is methylated, while the active allele is unmethylated. The most well-known conditions …

Mar 9, 2017 · DNA methylation and histone modifications play the key role in the process of imprinting. Imprinting clusters are susceptible to several mutations, deletions, and epigenetic …

Mar 17, 2025 · DNA methylation, a critical epigenetic modification, influences gene activity by adding methyl groups to cytosine bases, primarily at CpG dinucleotides. This process …

2 days ago · Methylation pattern of GNAS of individuals in the 1000 genomes project ONT sequencing consortium [].Methylation of the known imprinted gene GNAS of 452 haplotypes …

Jan 19, 2024 · Genomic imprinting (GI) is an original molecular phenomenon mediated by the apposition of epigenetic marks (DNA methylation and/or histone marks) leading to allele …

Dec 25, 1993 · Our results demonstrate that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes.

imprinting in most cases has a harmful effect on fetal devel-opment and can result in neurological, developmental, and metabolic disorders. Since DNA methylation and histone modifications …

Sep 1, 2002 · Experimental evidence supports the idea that chromatin organization, DNA methylation, replication timing, genomic domain organization, and more recently methylation …

Jul 15, 2005 · DNA methylation is a key epigenetic mechanism that controls developmental gene expression, transposon silencing, and genome integrity. In vertebrates, methylation occurs at …

Nov 25, 1993 · The functional significance of DNA methylation in genomic imprinting was strengthened by the recent finding that CpG islands (or sites) in three imprinted genes, H19, …

Dec 20, 2023 · One of the key mechanisms involved in imprinting is DNA methylation, which is an epigenetic modification that affects gene expression. Methylation patterns are established …

DNA methylation is a stable but not irreversible epigenetic signal that silences gene expression. It has a variety of important functions in mammals, including control of gene expression, cellular …

May 17, 2001 · Gene regulation by methylation includes tissue-specific gene regulation during development and also processes such as X-chromosome inactivation and genomic imprinting. …

Jan 31, 2011 · All cell lines showed changes in DNA methylation, especially at the paternal germ-line and the somatic DMRs. Our validated pyrosequencing methylation assays can be widely …

DNA methylation is also involved in X-chromosome inactivation and the allele-specific silencing of imprinted genes. This review describes possible mechanisms by which DNA methylation can …

DNA methylation is crucial for mammalian development because embryos that cannot maintain normal methylation levels die after gastrulation. I propose that DNA methylation is only …

Comprehensive physical models for the role of DNA methylation in imprinting must account not only for local allele-restricted gene expression but also for the existence of large chromosomal …

1 day ago · Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape …

Feb 20, 2025 · Background Alzheimer’s disease (AD) presents a significant public health problem and major cause of dementia. Not only genetic but epigenetic factors contribute to complex …

DNA methylation is crucial for mammalian development because embryos that cannot maintain normal methylation levels die after gastrulation. I propose that DNA methylation is only …

1 day ago · DNA methylation is an epigenetic mechanism modulating gene expression without altering the genetic sequence and plays a significant role in skin disorders. Methylation …