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Genomic imprinting. The role of DNA methylation in human diseases was first explored in the context of genomic imprinting. Genetic imprinting is an epigenetic phenomenon in which the …

Dec 25, 1993 · Our results demonstrate that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes.

Nov 25, 1993 · The functional significance of DNA methylation in genomic imprinting was strengthened by the recent finding that CpG islands (or sites) in three imprinted genes, H19, …

Mar 9, 2017 · DNA methylation and histone modifications play the key role in the process of imprinting. Imprinting clusters are susceptible to several mutations, deletions, and epigenetic …

Aug 1, 1997 · DNA methylation represents an attractive mechanism of 'genetic memory' because this epigenetic mark is clonally inherited and, thus, can distinguish the two alleles of imprinted …

DNA methylation, the first epigenetic mechanism to be associated with imprinting, is an epigenetic modification that is applied directly to a strand of DNA [18, 19].

DNA methylation is the mainstay of establishing imprinting marks on either paternal or maternal alleles. Besides, histone modifications and non-coding RNAs contribute greatly to imprinting …

Jul 15, 2005 · DNA methylation is a key epigenetic mechanism that controls developmental gene expression, transposon silencing, and genome integrity. In vertebrates, methylation occurs at …

Apr 1, 1997 · DNA methylation at cytosine residues is essential for functional imprinting of at least a subset of imprinted mammalian genes and pharmacological manipulation of DNA …

Genomic imprinting is an inheritance process independent of the classical Mendelian inheritance. [11] It is an epigenetic process that involves DNA methylation and histone methylation without …

Sep 1, 2002 · Experimental evidence supports the idea that chromatin organization, DNA methylation, replication timing, genomic domain organization, and more recently methylation …

DNA methylation is crucial for mammalian development because embryos that cannot maintain normal methylation levels die after gastrulation. I propose that DNA methylation is only …

2 days ago · Methylation pattern of GNAS of individuals in the 1000 genomes project ONT sequencing consortium [].Methylation of the known imprinted gene GNAS of 452 haplotypes …

Mar 17, 2025 · DNA methylation, a critical epigenetic modification, influences gene activity by adding methyl groups to cytosine bases, primarily at CpG dinucleotides. This process …

Jan 19, 2024 · We show here that enzymatic methyl-seq consistently outperforms the bisulfite-based standard in capturing 165 candidate regions for genomic imprinting in the pig. This …

1 day ago · Imprinting appears to be mostly due to differences in DNA methylation and histone marks. Imprinting disorders and uniparental disomy One of the earliest ways we discovered …

DNA methylation is also involved in X-chromosome inactivation and the allele-specific silencing of imprinted genes. This review describes possible mechanisms by which DNA methylation can …

Oct 22, 2024 · DNA-methylation is an epigenetic modification of DNA by the addition of methyl groups (-CH 3) which in turn results in changes to numerous processes including how genes …

Mar 21, 2025 · A comprehensive understanding of the molecular differences between X and Y sperm in Holstein bull semen is crucial for advancing sex control technologies. While previous …

1 day ago · Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape …