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Organizing and summarizing search results for youThe estrogen receptor pathway is crucial in various biological processes. Here are some key points:- Impact on Cancer Cells: Estrogen receptor-positive breast cancer cells can be influenced by compounds like black garlic extract, which inhibits their proliferation and promotes apoptosis.
These findings highlight the importance of estrogen receptors in both normal physiological functions and disease contexts.
PLOShttps://journals.plos.org › plosone › articleCrosstalk between Wnt/β-Catenin and Estrogen Receptor Signaling ... - PLOSWe find that the activation of estrogen receptor (ER) signaling by estradiol (E2) or exogenously expressed ERα in MPCs synergistically enhances Wnt3A-induced early and late osteoge…PLOShttps://journals.plos.org › plosone › articleXenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels - PLOS17β-estradiol (E2)-dependent estrogen receptor (ER) α intracellular concentration is a well recognized critical step in the pleiotropic effects elicited by E2 in several target tis…PLOShttps://journals.plos.org › plosone › articleAged black garlic extract inhibits the growth of estrogen receptor ...In this study, we found that the black garlic extract could inhibit the proliferation, invasion, and metastasis of estrogen receptor-positive breast cancer cells, promote their apo… Estrogen receptor signaling mechanisms - PMC
Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein …
See results only from pmc.ncbi.nlm.nih.govMolecular Pathways of Estrogen Receptor Action - PMCThe estrogen receptors (ERs) are typical members of the superfamily of nuclear receptors that includes the receptors that mediate the effects of steroid …A Basic Review on Estrogen Receptor Signaling Pathwa…Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review …Estrogen receptor signaling mechanisms - PubMedEstrogens exert their actions by binding to specific receptors, the estrogen receptors (ERs), which in turn activate transcriptional processes and/or …Role of estrogen receptors in health and disease - PMCEstrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including …The role of estrogen receptors in intracellular estrogen si…The structure and function of estrogen receptors, and interaction between ESR and coregulators were reviewed. In canonical pathway ESRs can translocate …A Basic Review on Estrogen Receptor Signaling Pathwa…Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review …Molecular Pathways of Estrogen Receptor Action - PMC
The estrogen receptors (ERs) are typical members of the superfamily of nuclear receptors that includes the receptors that mediate the effects of steroid hormones, thyroid hormones, retinoid …
A Basic Review on Estrogen Receptor Signaling Pathways in …
Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review summarizes current literature …
Estrogen receptor signaling mechanisms - PubMed
Estrogens exert their actions by binding to specific receptors, the estrogen receptors (ERs), which in turn activate transcriptional processes and/or signaling events that result in the control of …
- Author: Nathalie Fuentes, Patricia Silveyra, Patricia Silveyra
- Publish Year: 2019
Estrogen receptor - Wikipedia
Since estrogen is a steroidal hormone, it can readily diffuse through the phospholipid membranes of cells due to its lipophilic nature. As a result, estrogen receptors can be located intracellularly and do not necessarily need to be membrane-bound to interact with estrogen. However, both intracellular and membrane-bound estrogen receptors exist, each mediating different cellular responses to estrogen.
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Estrogen signaling pathway - Homo sapiens (human)
Estrogen mediates its cellular actions through two signaling pathways classified as "nuclear-initiated steroid signaling" and "membrane-initiated steroid signaling". In the "nuclear" pathway, estrogen binds either ERalpha or ERbeta, which in …
Estrogen Receptors: How Do They Signal and What …
In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling. Estrogens play key roles in …
Estrogen receptor signaling mechanisms - ScienceDirect
Jan 1, 2019 · Estrogens exert their actions by binding to specific receptors, the estrogen receptors (ERs), which in turn activate transcriptional processes and/or signaling events that result in the …
Nov 15, 2024 · In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti …
The role of estrogen receptors in intracellular estrogen signaling ...
Jan 1, 2025 · In canonical pathway ESRs can translocate to the nucleus, bind to the target gene promotor with or without estrogen responsive element and regulate transcription, mediating …
The role of estrogen receptors in intracellular estrogen signaling ...
The structure and function of estrogen receptors, and interaction between ESR and coregulators were reviewed. In canonical pathway ESRs can translocate to the nucleus, bind to the target …
Role of estrogen receptors in health and disease - PMC
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including reproductive system-related …
Estrogen synthesis and signaling pathways during aging: from …
Mar 1, 2013 · Estrogens act through two types of receptors: nuclear receptors (ERα and ERβ) and cell-membrane receptors (GPR30 and ER-X). Both types of estrogen receptors are expressed …
Molecular classification of hormone receptor-positive /HER2 …
2 days ago · We found that the T-cell receptor (TCR), B-cell receptor (BCR), PD-L1, and HIF-1 signaling pathways were significantly enriched in the ADC + TKI sensitivity group, whereas the …
A Basic Review on Estrogen Receptor Signaling Pathways in
Apr 6, 2023 · Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review summarizes current …
Molecular mechanism of estrogen–estrogen receptor signaling
17β-Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and …
Estrogen signaling pathway - PubChem
Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a …
The estrogen signaling pathway. The estrogen signaling mainly …
Differently, estrogens mediate non-ge nomic effects and activate intracellular signaling through the binding of the plasma membrane re ceptors, ER variants and the G protein-coupled receptor...
Estrogen receptor α suppresses hepatocellular carcinoma by …
22 hours ago · The estrogen receptor is a nuclear receptor family that includes ERα, estrogen receptor β, and membrane estrogen receptor G protein-coupled receptor 30. ERα (also known …
Estrogen Signaling Multiple Pathways to Impact Gene Transcription
The estrogen receptor β-isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and …
500 Elucidating the epigenetic regulation of estrogen receptor …
2 days ago · During human pregnancy, parathyroid hormone-related protein (PTHrP) and parathyroid hormone (PTH)/PTHrP receptor are produced by the uterus, placenta, fetal …
Estrogen Receptor Functions and Pathways at the Vascular
Apr 20, 2021 · ERα and ERβ are ligand-activated transcription factors of the nuclear hormone receptor superfamily, while the G protein-coupled estrogen receptor (GPER) mediates …
The many faces of estrogen signaling - PMC - PubMed Central …
Oct 15, 2021 · ERα and ERβ are mostly associated with the direct and indirect genomic signaling pathways that result in target gene expression. Membrane-bound GPER1 is on the other hand …
Using Combination PARP Inhibitor and Androgen Receptor …
Mar 20, 2025 · Combination PARP inhibitor and androgen receptor pathway inhibitor treatment benefits patients with metastatic castration-resistant prostate cancer with specific homologous …
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