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This review summarizes the rapidly developing field of epidermal stem cell research, paying particular attention to melanocyte stem cells, their biology and some of the processes that …

Apr 24, 2023 · Despite remarkable advances in our understanding of melanoma biology and genetics, the melanoma cell of origin is still fiercely debated because both melanocyte stem …

Melanocyte stem cells (MSCs), melanocyte lineage‐specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the sweat gland. …

The cellular origin and development of melanocytes during embryogenesis are extensively investigated. Many studies have also identified the role of melanocyte stem cells (McSCs) in …

In this review, we describe ectopic factors which drive human pluripotent stem cell differentiation to melanocytes in 2D, as well as in organoid models. Furthermore, we compare developmental …

May 22, 2024 · Melanocyte stem cells (MSCs), melanocyte lineage-specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the …

Mar 1, 2013 · Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role …

Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSC) that are present in hair bulges or sub-bulge …

Melanocyte stem cells (MSCs), melanocyte lineage-specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the sweat gland. …

The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely …

Sep 8, 2023 · We differentiated human embryonic stem cells (hESCs) that transiently express JMJD3 to pigmented cells. We investigated whether the pigmented cells have melanocytic …

May 2, 2023 · Melanocytes are the cells that produce the pigment responsible for skin and hair color. They arise from melanocyte stem cells (McSCs). McSCs fail earlier than the hair follicle …

Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem …

In melanoma, high MITF activity correlates with a relatively proliferative and pigmented phenotype and with high expression of genes promoting these qualities, while low MITF activity correlates …

Introduction: Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSCs) that are present in hair bulges or …

Apr 8, 2005 · Two recent papers provide compelling evidence that hair graying is due to incomplete melanocyte stem cell maintenance and identify Pax3 and Mitf as key molecules …

As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and …

Feb 25, 2025 · Predominantly made up of keratinocytes, along with melanocytes, Langerhans cells, and Merkel cells. Sublayers of the Epidermis (From Deepest to Superficial) While the …

4 days ago · The mammalian hair follicle (HF) serves as a valuable model for studying tissue patterning, regeneration, as well as stem cell biology. In mice, HF morphogenesis begins with …

5 days ago · Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes. …

Mar 18, 2025 · Background Hematopoietic stem cell transplantation (HSCT) is a critical treatment for hematologic disorders such as leukemia, lymphoma, and specific immune deficiencies. …

Oct 19, 2022 · In addition to prostaglandins and leukotrienes, biological substances that promote melanogenesis include MSH [45,46], adrenocorticotropic hormone (ACTH) , and other factors …

Sep 2, 2021 · Those with a melanocyte stem cell signature (MSC) or a foetal melanocyte signature (FET) were associated with moderate survival, with high druggability or high immune …

Feb 22, 2025 · In glioblastoma (GBM) stem cells, METTL3 and YTHDF2 have been implicated in Yin Yang 1 (YY1)-mediated IFN-β signaling and antigen presentation through m6A …