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This review summarizes the rapidly developing field of epidermal stem cell research, paying particular attention to melanocyte stem cells, their biology and some of the processes that …

Melanocyte stem cells (MSCs), melanocyte lineage‐specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the sweat gland. …

The cellular origin and development of melanocytes during embryogenesis are extensively investigated. Many studies have also identified the role of melanocyte stem cells (McSCs) in …

Mar 1, 2013 · Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role …

Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSC) that are present in hair bulges or sub-bulge …

Sep 8, 2023 · We differentiated human embryonic stem cells (hESCs) that transiently express JMJD3 to pigmented cells. We investigated whether the pigmented cells have melanocytic …

Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem …

Introduction: Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSCs) that are present in hair bulges or …

May 22, 2024 · Melanocyte stem cells (MSCs), melanocyte lineage-specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the …

Melanocyte stem cells (MSCs), melanocyte lineage-specific skin stem cells derived from the neural crest, are observed in the mammalian hair follicle, the epidermis or the sweat gland. …

In this review, we describe ectopic factors which drive human pluripotent stem cell differentiation to melanocytes in 2D, as well as in organoid models. Furthermore, we compare developmental …

Feb 25, 2025 · Predominantly made up of keratinocytes, along with melanocytes, Langerhans cells, and Merkel cells. Sublayers of the Epidermis (From Deepest to Superficial) While the …

5 days ago · The mammalian hair follicle (HF) serves as a valuable model for studying tissue patterning, regeneration, as well as stem cell biology. In mice, HF morphogenesis begins with …

Dec 21, 2015 · Recent advances in human pluripotent stem cell (hPSC) research have provided us with useful tools to potentially acquire a substantial amount of human McSCs and functional …

6 days ago · Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes. …

Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations. The stem cells are regulated …

Feb 25, 2025 · Singh, Fernandez-Perez, et al. use hematopoietic stem cell barcoding to study clones with and without activation of cancer driver mutations, identifying that pre-existing stem …

As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and …

Feb 25, 2025 · Cancer cells display striking phenotypic variation, within and across patients, yet the origins of this variation are still unclear. 1 Since cancer is a clonal disorder, researchers …

1 day ago · Although immune checkpoint (IC) inhibition is a major treatment modality in cancer-immunotherapy, multiple cancers show low response. Our in-silico exploration by mining …

Jun 30, 2009 · Melanocyte stem cells offer an advantageous model by which to elucidate molecular basis of stem cell regulation, since genetic alterations affecting melanocyte …

Dec 21, 2015 · Recent advances in human pluripotent stem cell (hPSC) research have provided us with useful tools to potentially acquire a substantial amount of human McSCs and functional …

Feb 22, 2025 · In glioblastoma (GBM) stem cells, METTL3 and YTHDF2 have been implicated in Yin Yang 1 (YY1)-mediated IFN-β signaling and antigen presentation through m6A …

We found that SR-B1 depletion in melanoma cells does not alter total cholesterol levels, but induces cholesterol biosynthesis. ... Finally, we used a pluripotent stem cell-derived skin …