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Nov 5, 2023 · Unmethylated cytosine-phosphate-guanine (CpG) DNA is recognized by Toll-like receptor 9, expressed in the endosomes of immune cells, and induces the secretion of …

Unmethylated CpG motifs are prevalent in bacterial but not vertebrate genomic DNAs. Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms …

DNA molecules containing unmethylated CpG-dinucleotides in particular base contexts (“CpG motifs”) are excellent adjuvants in rodents, but their effects on human cells have been less clear.

TLR9 is thought to be able to activate the innate immune cells by detecting the unmethylated CpG dinucleotides, which are common in the genomes of most of the bacteria and DNA viruses.

May 26, 2021 · Here, we report the molecular mechanisms of how the TCF (T-cell factor) and GEF (glucose transporter 4 enhancer factor) families of proteins selectively target …

It is becoming increasingly clear that bacterial CpG DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG are potent inducers of the innate immune system …

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) to …

Sep 2, 2023 · DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high …

Jul 1, 1999 · Unmethylated CpG motifs are ∼20-fold more common in bDNA than in vertebrate DNA. CpG motifs appear to be underrepresented in vertebrate genomes; when present, they …

2 days ago · The proposed method achieves a detection limit of 0.15 pM and can differentiate methylation levels as low as 0.1 %, even in the presence of a large excess of unmethylated …

Jun 1, 2010 · TLR9 recognizes CpG motifs present in pathogenic DNA and triggers potent immune responses. It is generally accepted that TLR9 distinguishes pathogenic DNA based, in …

CGIs are generally unmethylated CpG-enriched domains that occur against a backdrop of genome-wide DNA methylation and consequent CpG depletion. How are they protected from …

Jul 16, 2015 · Bacterial DNA has unmethylated Cytosine-phosphor-Guanine (CpG) motifs, while mammals generally have methylated CpG motifs which are close to anti-inflammatory DNA …

Oct 1, 2013 · Our results suggest that unmethylated and methylated CpG patterns can play very different roles in regulating the physical properties of DNA. CpG methylation seems to reduce …

Our results suggest that unmethylated and methylated CpG patterns can play very different roles in regulating the physical properties of DNA. CpG methylation seems to reduce the DNA …

Mar 11, 2025 · DNA methylation level of each CpG site was calculated as “β values” (corresponding to \(\:\frac{\text{methylated signal}}{\text{methylated + unmethylated …

May 13, 2021 · Here, we report the molecular mechanisms of how the TCF (T-cell factor) and GEF (glucose transporter 4 enhancer factor) families of proteins selectively target unmethylated …

Mar 24, 2025 · a) DNA methylation at the most age-associated CpG site in PDE4C was measured by digital droplet PCR in peripheral blood, as described before (n = 80, R 2 = 0.76; Han et al., …

Validation: Methylation-specific PCR (MSP) was performed on the DNA prior to and post-enzymatic methylation. Sets of primers from the CpG WIZ p15 and E-cadherin Amplification …

Unmethylated CpG motif-containing genomic DNA fragment of Bacillus calmette-guerin promotes macrophage functions through TLR9-mediated activation of NF- κ B and MAPKs signaling …

Nov 5, 2023 · Unmethylated cytosine-phosphate-guanine (CpG) DNA is recognized by Toll-like receptor 9, expressed in the endosomes of immune cells, and induces the secretion of …