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Estrogens can be synthesized in non-reproductive tissue as liver, heart, muscle, bone and brain. The tissue-specific estrogen synthesis is consistent with a diversity of estrogen actions. Here, …

We investigated the hypothesis that ERs and functional single-nucleotide polymorphisms in the estrogen biosynthesis pathway are associated with poorer lung cancer survival. Lung cancer …

In this review, we will summarize recent discoveries of extra-gonadal sites of estrogen biosynthesis and their local functions and discuss the significance of the most recent novel …

This review provides a comprehensive exploration of estrogen biosynthesis, including its genomic and non-genomic pathways. It examines the classes, quantitative structure-activity …

Apr 6, 2022 · Estrogen improves vascular smooth muscle relaxation by activating NO-cGMP pathway [4]. Estrogen regulates the growth of bone tissue, and endogenous estrogen levels …

Teleost sex steroids (estrogens and androgens) are synthesized through pathways involving cholesterol as the main precursor and require numerous enzymes similar to those of other …

Mar 1, 2013 · Here, we review tissue- and cell-specific aspects of estrogen from several perspectives: (i) estrogen synthesis, (ii) estrogen receptors (ERs) and signaling pathways, and …

In this review, we summarized the current knowledge of the estrogen synthesis in the ovaries. A series of factors and signaling pathways that regulate the synthesis of estrogen are …

Biosynthesis of Estrogen: Estrogens are a family of hormones synthe­sized in a variety of tissues. 1 7p-estradiol (E 2 ) is the primary estrogen of ovarian hormone. Cholesterol is the precursor …

Jan 23, 2013 · In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen …

Jan 21, 2013 · In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen...

In this article we review tissue and cell-specific estrogen synthesis and estrogen receptor signaling in three parts: (i) synthesis and metabolism, (ii) the distribution of estrogen receptors …

Mar 21, 2025 · Lipid metabolism and the serine, one-carbon, glycine (SOG) and methionine pathways are independently and significantly correlated with estrogen receptor–negative …

Follicular estrogen production is regulated by a complex set of signals that synergize to produce optimal steroidogenesis. Most importantly, the effect of estrogen is truly an endocrine effect, as …

Estrogen liganded with ER gets transported into the cell, where it binds with E2F and ERE, activating E2- regulated genes in a classical pathway, ultimately promoting abnormal cellular …

Mar 22, 2022 · Estrogen mainly binds to estrogen receptors (ERs) to regulate menstrual cycles and reproduction. The expression of ERalpha (ERα), ERbeta (ERβ), and G-protein-coupled …

1 day ago · The estrogen receptor α (ERα) pathway may play a key role. The aim of the present study was to confirm the role of adipose/hypothalamic ERα in HIT/MIT-mediated VAT loss, as …

1 day ago · Notably, estrogen has been explicated to periodically fluctuate during female menstrual cycle, causing several cyclic biological changes, including the renovation and …

1 day ago · The estrogen receptor α (ERα) pathway may play a key role. The aim of the present study was to confirm the role of adipose/hypothalamic ERα in HIT/MIT-mediated VAT loss, as …

Three major forms of physiological estrogens are present in females: estrone (E1), estradiol (E2, or 17β-estradiol), and estriol (E3). E2 is the major product of the entire biosynthesis process …